The effector function of IgG antibodies is dependent on the IgG subclass and the IgG Fc N-glycosylation pattern. Our laboratory investigates the development and function of differentially glycosylated IgG subclass antibodies.
In this project we investigate the potential of differently glycosylated IgG antibodies to attenuate IgG-mediated and IgG-controlled IgE-mediated anaphylactic reactions. As it is known that the kind of IgG glycosylation is associated with the severity of inflammatory autoimmune diseases and that IgE antibodies can also play a role in certain autoimmune diseases like systemic lupus erythematosus and bullous pemphigoid (BP), our studies might further elucidate their role in autoimmunity and give some new ideas for treatment options of autoimmune diseases.

References:
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