MD TP21: Influence of NF-κB on the pathogenesis of EBA

Previous studies could show that antibodies from autoimmune bullous diseases induce an altered cytokine liberation in keratinocytes.

By stimulating cultured human keratinocytes with antibodies from patients with Epidermolysis bullosa acquisita (EBA), we want to investigate the impact of NF-κB on the release of mediators by these cells, and further want to elucidate intra- and extracellular pathways leading to NF-κB activation by EBA antibodies.