In the preceding project we identified that neutrophils release IL-16 and MIF (TP 5). Here we will follow up on this observation, and investigate the functional role of these 2 cytokines in the context of autoimmunity. Based on the observations in the associated TP4 that T cell-mediated antibody production is supported by neutrophils (J Immunol 2014), we will focus on the role of these 2 neutrophil derived cytokines during the loss of tolerance. 

Gigy received her Dr. rer. nat degree inn November 2017. Congratulations!